Caspase-3 activator 4
Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier caspase-3 activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3.
For research use only. We do not sell to patients.
- CAS No.: 1817874-62-6
- Formula: C31H27N5O3
- Molecular Weight:517.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Caspase Isoforms
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Biological Activity
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LN-229 | IC50 |
>100 μM
Compound: Pseudellone C
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Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay
Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay
|
[PMID: 39213937] |
| U-87MG ATCC | IC50 |
168.2 μM
Compound: Pseudellone C
|
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay
|
[PMID: 39213937] |
Chemical Information
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CAS No. 1817874-62-6
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Molecular Weight 517.58
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Formula C31H27N5O3
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SMILES
CC(C(N[C@@H](C(C1=CNC2=C1C=CC=C2)=O)C(NC)=O)=O)(C3=CNC4=C3C=CC=C4)C5=CNC6=C5C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)