KBH-A42
KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC50 values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells.
For research use only. We do not sell to patients.
- CAS No.: 798543-50-7
- Formula: C17H22N2O3
- Molecular Weight:302.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ACHN | GI50 |
1.17 μM
Compound: 14c
|
Growth inhibition of ACHN cells by SRB assay
Growth inhibition of ACHN cells by SRB assay
|
[PMID: 17477518] |
| ACHN | GI50 |
1.17 μM
Compound: 4h
|
Cytotoxicity against human ACHN cells
Cytotoxicity against human ACHN cells
|
[PMID: 21256006] |
| HCT-15 | GI50 |
4.99 μM
Compound: 14c
|
Growth inhibition of HCT15 cells by SRB assay
Growth inhibition of HCT15 cells by SRB assay
|
[PMID: 17477518] |
| HCT-15 | GI50 |
4.99 μM
Compound: 4h
|
Cytotoxicity against human HCT15 cells
Cytotoxicity against human HCT15 cells
|
[PMID: 21256006] |
| HeLa | IC50 |
0.27 μM
Compound: 14c
|
Inhibition of HDAC in HeLa cells by fluorescent activity assay
Inhibition of HDAC in HeLa cells by fluorescent activity assay
|
[PMID: 17477518] |
| LOX IMVI | GI50 |
3.34 μM
Compound: 14c
|
Growth inhibition of LOX-IMVI cells by SRB assay
Growth inhibition of LOX-IMVI cells by SRB assay
|
[PMID: 17477518] |
| LOX IMVI | GI50 |
3.34 μM
Compound: 4h
|
Cytotoxicity against human LOXIMVI cells
Cytotoxicity against human LOXIMVI cells
|
[PMID: 21256006] |
| MDA-MB-231 | GI50 |
0.5 μM
Compound: 14c
|
Growth inhibition of human MDA-MB-231 cells by SRB assay
Growth inhibition of human MDA-MB-231 cells by SRB assay
|
[PMID: 17477518] |
| MDA-MB-231 | GI50 |
0.5 μM
Compound: 4h
|
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
|
[PMID: 21256006] |
| NCI-H23 | GI50 |
3.79 μM
Compound: 14c
|
Growth inhibition of NCI-H23 cells by SRB assay
Growth inhibition of NCI-H23 cells by SRB assay
|
[PMID: 17477518] |
| NCI-H23 | GI50 |
3.79 μM
Compound: 4h
|
Cytotoxicity against human NCI-H23 cells
Cytotoxicity against human NCI-H23 cells
|
[PMID: 21256006] |
| PC-3 | GI50 |
5.04 μM
Compound: 14c
|
Growth inhibition of PC3 cells by SRB assay
Growth inhibition of PC3 cells by SRB assay
|
[PMID: 17477518] |
| PC-3 | GI50 |
6.98 μM
Compound: 4h
|
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
|
[PMID: 21256006] |
| RAW264.7 | IC50 |
1.1 μM
Compound: 14c
|
Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA
|
[PMID: 17477518] |
| RAW264.7 | IC50 |
2.71 μM
Compound: 14c
|
Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA
|
[PMID: 17477518] |
Chemical Information
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CAS No. 798543-50-7
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Molecular Weight 302.37
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Formula C17H22N2O3
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SMILES
O=C(CCC1=CCCN(C1=O)CCCC2=CC=CC=C2)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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