WM-A1-3389
WM-A1-3389 is an anti-human IGSF1monoclonal antibody and tumor growth inhibitor. WM-A1-3389 specifically binds to the C-terminus of IGSF1, increases secretion of Granzyme B, IFN?γ, and TNF?α, and inhibits growth of colon cancer or biliary tract cancer in xenogeneic or allogeneic mouse implantation models. WM-A1-3389 can be used for the research of colon cancer, biliary tract cancer, and head and neck cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
WM-A1-3389 antibody (24 h) significantly increases secretion of Granzyme B, IFN?γ, and TNF?α in a co-culture system of human colon cancer HT29 cells and hPBMCs[1].
WM-A1-3389 antibody (24 h) significantly increases secretion of Granzyme B, IFN?γ, and TNF?α in a co-culture system of human biliary tract cancer Choi-CK cells and hPBMCs[1].
WM-A1-3389 antibody (24 h) significantly increases secretion of Granzyme B, IFN?γ, and TNF?α in a co-culture system of human head and neck cancer FaDu cells and hPBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
WM-A1-3389 antibody (3-30 mg/kg; i.p.; once every three days; two weeks) achieves dose-dependent tumor growth inhibition (50.8% to 68.7%) in C57BL/6N mice bearing MC38 colon cancer allografts[1].
WM-A1-3389 antibody (3-50 mg/kg; i.p.; once every three days; two weeks) achieves dose-dependent tumor growth inhibition (44.9% to 66.0%) in C57BL/6N mice bearing CT26 colon cancer allografts[1].
WM-A1-3389 antibody (30 mg/kg; i.p.; once every three days; three weeks) achieves 58.0 ± 4.3% tumor growth inhibition in humanized mice bearing Choi-CK biliary tract cancer xenografts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:peripheral blood mononuclear cell humanized mice (6-week-old female; subcutaneous implantation of human colon cancer cell line HT29 cells)[1]
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Dosage:30 mg/kg
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Administration:i.p.; once every three days; four weeks
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Result:Achieved 55.5% tumor growth inhibition relative to the negative control group, with a statistically.
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Animal Model:C57BL/6N mice (5-week-old female; subcutaneous implantation of mouse colon cancer cell line MC38 cells)[1]
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Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:i.p.; once every three days; two weeks
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Result:Achieved 50.8% tumor growth inhibition relative to the negative control group at 3 mg/kg.
Achieved 58.2% tumor growth inhibition relative to the negative control group at 10 mg/kg.
Achieved 68.7% tumor growth inhibition relative to the negative control group at 30 mg/kg.
Showed a dose-dependent increase in tumor growth inhibition.
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Animal Model:C57BL/6N mice (5-week-old female; subcutaneous implantation of mouse colon cancer cell line CT26 cells)[1]
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Dosage:3 mg/kg; 10 mg/kg; 50 mg/kg
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Administration:i.p.; once every three days; two weeks
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Result:Achieved 44.9% tumor growth inhibition relative to the negative control group at 3 mg/kg.
Achieved 57.0% tumor growth inhibition relative to the negative control group at 10 mg/kg.
Achieved 66.0% tumor growth inhibition relative to the negative control group at 50 mg/kg.
Showed a dose-dependent increase in tumor growth inhibition.
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Animal Model:peripheral blood mononuclear cell humanized mice (6-week-old female; subcutaneous implantation of human biliary tract cancer cell line Choi-CK cells)[1]
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Dosage:30 mg/kg
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Administration:i.p.; once every three days; three weeks
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Result:Achieved 58.0% tumor growth inhibition relative to the negative control group, with a statistically.
Q8N6C5
IGSF1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[WM-A1-3389]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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