2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Angiotensin-converting Enzyme (ACE) Toll-like Receptor (TLR) Interleukin Related
  4. Ganoderic acid K

Ganoderic acid K is a triterpenoid compound. Ganoderic acid K can be isolated from Ganoderma lucidum. Ganoderic acid K inhibits ACE activity with an IC50 of 2.6×10-5 M. Ganoderic acid K exhibits direct, high-affinity binding to recombinant MD2 protein, with a Kd value of 0.47 μM. It potently inhibits LPS-induced release of TNF-α and IL-6. It reduces cerebral infarction volume and ameliorates neurological dysfunction in mice with ischemic stroke in the tMCAO model. Ganoderic acid K can be used in studies related to hypertension and ischemic stroke.

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Ganoderic acid K

Ganoderic acid K Chemical Structure

CAS No. : 104700-95-0

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Ganoderic acid K Related Antibodies

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Description

Ganoderic acid K is a triterpenoid compound. Ganoderic acid K can be isolated from Ganoderma lucidum. Ganoderic acid K inhibits ACE activity with an IC50 of 2.6×10-5 M. Ganoderic acid K exhibits direct, high-affinity binding to recombinant MD2 protein, with a Kd value of 0.47 μM. It potently inhibits LPS-induced release of TNF-α and IL-6. It reduces cerebral infarction volume and ameliorates neurological dysfunction in mice with ischemic stroke in the tMCAO model. Ganoderic acid K can be used in studies related to hypertension and ischemic stroke[1][2].

IC50 & Target[1]

IL-6

 

In Vitro

Ganoderic acid K inhibits the activity of purified porcine kidney angiotensin-converting enzyme, with an IC50 value of 2.6×10-5 M[1].
Ganoderic acid K (25 μM; 1 h pretreatment) potently inhibits LPS-induced release of TNF-α and IL-6 in BV-2 mouse microglia, with inhibition rates of over 50% for both cytokines[2].
Ganoderic acid K (0.19-50 μM) exhibits direct, high-affinity binding to recombinant MD2 protein, with a Kd value of 0.47 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid K Related Antibodies

Cell Viability Assay[2]

Cell Line: BV-2 murine microglial cells
Concentration: 12.5, 25, 50, 100 μM
Incubation Time: 24 h
Result: Showed no cytotoxicity to BV-2 cells at all tested concentrations.

ELISA Assay[2]

Cell Line: LPS-stimulated BV-2 murine microglial cells
Concentration: 25 μM (pretreatment); 10 ng/mL LPS
Incubation Time: 1 h (pretreatment); 12 h (LPS incubation)
Result: Significantly inhibited LPS-induced TNF-α and IL-6 release by more than 50% each.
Demonstrated the most pronounced inhibitory effect among the eight tested ganoderic acid monomers.
In Vivo

Ganoderic acid K (20 mg/kg; i.p.; single dose) significantly reduces cerebral infarct volume and neurological dysfunction in a mouse tMCAO model of ischemic stroke[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (8-week-old male, 23 g)[2]
Dosage: 20 mg/kg
Administration: Not specified
Result: Significantly reduced cerebral infarct volume compared to vehicle-treated tMCAO mice.
Exhibited significantly lower neurological deficit scores relative to vehicle-treated tMCAO controls.
Molecular Weight

574.70

Formula

C32H46O9
CAS No.
SMILES

C[C@@H]([C@H]1CC([C@]2(C)[C@]1(C)[C@H](OC(C)=O)C(C3=C2[C@@H](O)CC4[C@]3(C)CC[C@H](O)C4(C)C)=O)=O)CC(C[C@H](C(O)=O)C)=O
Initial Source

Ganoderma lucidum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ganoderic acid K Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganoderic acid K104700-95-0Angiotensin-converting Enzyme (ACE)Toll-like Receptor (TLR)Interleukin RelatedILNF-κBmouse tMCAO modelMAPKcerebral ischemic injuryhuman MD2porcine ACEangiotensin converting enzymeTLR4BV-2 murine microglial cellsmyeloid differentiation protein 2Inhibitorinhibitorinhibit

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