2. Immunology/Inflammation
  3. Interleukin Related
  4. Serrumab

Serrumab is a human monoclonal antibody that counteracts the biochemical and immunological effects of Tityus serrulatus venom. Serrumab inhibits the TsV-induced increase in the production of IL-6, TNFα and IL-10. Serrumab also prevents TsV-induced elevations in plasma urea, creatinine, aspartate transaminase and glucose levels, as well as the TsV-induced increase in neutrophil recruitment. Serrumab can be used in research related to envenoming by the Brazilian yellow scorpion.

For research use only. We do not sell to patients.

Serrumab

Serrumab Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Serrumab Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Serrumab is a human monoclonal antibody that counteracts the biochemical and immunological effects of Tityus serrulatus venom. Serrumab inhibits the TsV-induced increase in the production of IL-6, TNFα and IL-10. Serrumab also prevents TsV-induced elevations in plasma urea, creatinine, aspartate transaminase and glucose levels, as well as the TsV-induced increase in neutrophil recruitment. Serrumab can be used in research related to envenoming by the Brazilian yellow scorpion[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Tityus serrulatus
IC50 & Target[1]

IL-6

 

IL-10

 

In Vitro

Serrumab (10-20 μg/mL; 60 min pre-incubation with TsV, 24 h incubation with cells) inhibits TsV-induced IL-6 and TNF-α production in J774.1 murine peritoneal macrophages, with 10 μg/mL also inhibiting TsV-induced IL-10 production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Serrumab Related Antibodies
In Vivo

Serrumab (10-20 µg per animal; administered via injection) completely prevents changes in biochemical parameters (urea, creatinine, AST, glucose) and immunological parameters (neutrophil recruitment) induced by *Tityus serrulatus* venom in male BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 15-25 g)[1]
Dosage: 10 µg per animal; 20 µg per animal
Administration: injection
Result: Prevented venom-induced increases in plasma urea, creatinine, and aspartate transaminase (AST) levels, with values not significantly different from control mice.
Prevented venom-induced increases in neutrophil recruitment, with neutrophil percentages matching control levels.
Prevented venom-induced hyperglycemia (observed 1-4 hours post-venom injection) and subsequent hypoglycemia (observed 5 hours post-venom injection), maintaining glucose levels within the normal control range over the 24-hour monitoring period.
Target

Tityustoxin VIIToxin VIITs7
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Serrumab]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Serrumab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SerrumabInterleukin RelatedILTityus serrulatus venomtumor necrosis factor (TNF)-αneutrophil recruitmentmale BALB/c miceJ774.1 murine peritoneal macrophagestityus serrulatus scorpion envenomationinterleukin (IL)-6IL-10murine peritoneal macrophagesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Serrumab
Cat. No.:
HY-P992153
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.