2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. (6R,7R)-Epoxy-1-oleanen-3-ol

(6R,7R)-Epoxy-1-oleanen-3-ol is a triterpenoid that can be found in Boswellia ovalifoliolata, exhibiting anti-inflammatory activity. (6R,7R)-Epoxy-1-oleanen-3-ol inhibits TNF-α, IL-6, IL-8, and NO production in LPS (HY-D1056)-activated murine neutrophils. (6R,7R)-Epoxy-1-oleanen-3-ol can be used for the research on inflammatory conditions.

For research use only. We do not sell to patients.

(6R,7R)-Epoxy-1-oleanen-3-ol

(6R,7R)-Epoxy-1-oleanen-3-ol Chemical Structure

CAS No. : 1609645-89-7

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(6R,7R)-Epoxy-1-oleanen-3-ol Related Antibodies

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Description

(6R,7R)-Epoxy-1-oleanen-3-ol is a triterpenoid that can be found in Boswellia ovalifoliolata, exhibiting anti-inflammatory activity. (6R,7R)-Epoxy-1-oleanen-3-ol inhibits TNF-α, IL-6, IL-8, and NO production in LPS (HY-D1056)-activated murine neutrophils. (6R,7R)-Epoxy-1-oleanen-3-ol can be used for the research on inflammatory conditions[1].

IC50 & Target[1]

IL-6

 

IL-8

 

In Vitro

(6R,7R)-Epoxy-1-oleanen-3-ol (compound 2) (1 μM; 3 h) significantly inhibits intracellular TNF-α expression by 55.01% in LPS-activated murine neutrophils[1].
(6R,7R)-Epoxy-1-oleanen-3-ol (1 μM) significantly reduces intracellular IL-6 and IL-8 levels in LPS-activated murine neutrophils[1].
(6R,7R)-Epoxy-1-oleanen-3-ol (1 μM; 4-5 h) significantly inhibits extracellular NO production in LPS-activated murine neutrophils[1].
(6R,7R)-Epoxy-1-oleanen-3-ol (1-100 μM) shows no cytotoxicity in THP1, COLO-205, or A549 cells at 1 μM or 10 μM but inhibits growth by 77% (THP1) and 81% (A549) at 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(6R,7R)-Epoxy-1-oleanen-3-ol Related Antibodies

ELISA Assay[1]

Cell Line: murine neutrophils
Concentration: 1 μM
Incubation Time: 4-5 h
Result: Significantly inhibited extracellular NO production in murine neutrophils.
Reduced NO levels from 237.74 to 139.66 μmol/mL.
Molecular Weight

440.70

Formula

C30H48O2
CAS No.
SMILES

C[C@@]12[C@@]3([H])[C@]([C@]4([H])[C@@](C1=CC[C@@]5([H])[C@]2(CC[C@@]6([C@@]5([H])CC(C)(CC6)C)C)C)(CC[C@H](C4(C)C)O)C)([H])O3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(6R,7R)-Epoxy-1-oleanen-3-ol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(6R,7R)-Epoxy-1-oleanen-3-ol1609645-89-7TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILNOmurine neutrophilsIL-6Boswellia ovalifoliolatainterleukin-8nitric oxideinterleukin-6tumor necrosis factor-alphaTNF-αIL-8Inhibitorinhibitorinhibit

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(6R,7R)-Epoxy-1-oleanen-3-ol
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