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Potassium sorbate  (Synonyms: Sorbic acid potassium)

Cat. No.: HY-N0626A Purity: 98.0%
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Potassium sorbate (Sorbic acid potassium) is an antibacterial preservative effective against most molds, yeasts, and some bacterial species. Potassium sorbate inhibits microbial growth. Potassium sorbate suppresses the activity of intestinal microorganisms in zebrafish, alters the composition of intestinal flora, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α. Potassium sorbate can be used in research on the prevention and treatment of mold, yeast, and bacterial infections.

For research use only. We do not sell to patients.

Potassium sorbate

Potassium sorbate Chemical Structure

CAS No. : 24634-61-5

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Based on 1 publication(s) in Google Scholar

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Description

Potassium sorbate (Sorbic acid potassium) is an antibacterial preservative effective against most molds, yeasts, and some bacterial species. Potassium sorbate inhibits microbial growth. Potassium sorbate suppresses the activity of intestinal microorganisms in zebrafish, alters the composition of intestinal flora, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α. Potassium sorbate can be used in research on the prevention and treatment of mold, yeast, and bacterial infections[1][2][3].

In Vitro

Potassium sorbate (0.05%-0.1%) extends the shelf life of cottage cheese, inhibits the growth of Penicillium frequentans and other spoilage microorganisms, suppresses spoilage bacteria in cottage cheese as well as molds in unsalted butter and grains, and prolongs the safe storage period of grains[1].
Potassium sorbate (0.02%-0.04%) inhibits the growth of molds in ham and sausage, as well as the growth of Aspergillus versicolor, inhibits the growth of Alternaria solani, Penicillium citrinum and Aspergillus niger, with minimum inhibitory concentrations of 0.02%, 0.08% and 0.08%, respectively[1].
Potassium sorbate (0.05-0.15%) delays or prevents spore germination and growth initiation of Aspergillus parasiticus and Aspergillus flavus strains, slows their hyphal growth, inhibits the growth of Aspergillus sulphureus and Penicillium viridicatum as well as their ability to produce ochratoxin A, and reduces or even blocks the production of aflatoxin B1 by Aspergillus parasiticus and Aspergillus flavus[1].
Potassium sorbate (0.05%) inhibits the growth of Zygosaccharomyces rouxii, Saccharomyces bisporus, Saccharomyces acidifaciens and Saccharomyces pastorianus, and is used in combination with acids[1].
Incorporation of potassium sorbate (≥15%) into sweet potato starch films significantly inhibits the growth of E. coli, but exerts no inhibitory effect on S. aureus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Exposure to potassium sorbate (0.1-1 g/L; aqueous exposure; daily water replacement; 14 days) inhibits intestinal microbial activity, alters intestinal flora composition, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Danio rerio (4-month-old adults)[2]
Dosage: 0.1 g/L; 1 g/L
Administration: aqueous exposure; daily water replacement; 14 days
Result: Decreased levels of intestinal IgG, IL-1β, and TNF-α. Altered core gut microbiota development, with Pelomonas becoming the most abundant genus (accounting for 32.77% of gut microbiota), while Reyranella and Sphingomonas decreased, and Rhizobacter increased. Decreased relative abundance of transcription, energy metabolism, and cancer pathways. Significantly reduced the gut microbiota activity index (AIM).
Molecular Weight

150.22

Formula

C6H7KO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C=C/C=C/C([O-])=O.[K+]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (332.85 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6569 mL 33.2845 mL 66.5690 mL
5 mM 1.3314 mL 6.6569 mL 13.3138 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.6569 mL 33.2845 mL 66.5690 mL 166.4226 mL
5 mM 1.3314 mL 6.6569 mL 13.3138 mL 33.2845 mL
10 mM 0.6657 mL 3.3285 mL 6.6569 mL 16.6423 mL
15 mM 0.4438 mL 2.2190 mL 4.4379 mL 11.0948 mL
20 mM 0.3328 mL 1.6642 mL 3.3285 mL 8.3211 mL
25 mM 0.2663 mL 1.3314 mL 2.6628 mL 6.6569 mL
30 mM 0.2219 mL 1.1095 mL 2.2190 mL 5.5474 mL
40 mM 0.1664 mL 0.8321 mL 1.6642 mL 4.1606 mL
50 mM 0.1331 mL 0.6657 mL 1.3314 mL 3.3285 mL
60 mM 0.1109 mL 0.5547 mL 1.1095 mL 2.7737 mL
80 mM 0.0832 mL 0.4161 mL 0.8321 mL 2.0803 mL
100 mM 0.0666 mL 0.3328 mL 0.6657 mL 1.6642 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Potassium sorbate
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