1. Metabolic Enzyme/Protease
    Apoptosis
  2. MMP
    TNF Receptor
  3. Apratastat

Apratastat 

Cat. No.: HY-119307 Purity: 99.28%
Handling Instructions

Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively.

For research use only. We do not sell to patients.

Apratastat Chemical Structure

Apratastat Chemical Structure

CAS No. : 287405-51-0

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1 mg USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].

IC50 & Target

MMP

 

TNF-α

 

Molecular Weight

414.50

Formula

C₁₇H₂₂N₂O₆S₂

CAS No.

287405-51-0

SMILES

CC1(C)[[email protected]](C(NO)=O)N(S(=O)(C2=CC=C(OCC#CCO)C=C2)=O)CCS1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Apratastat
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HY-119307
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