2. Others Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Membrane Transporter/Ion Channel Apoptosis
  3. Drug Derivative HMG-CoA Reductase (HMGCR) PPAR ATP-binding cassette (ABC) transporters TNF Receptor
  4. NO-Pravastatin

NO-Pravastatin is a derivative of Pravastatin (HY-B0165) covalently linked with an NO donor moiety, endowing it with dual functions of HMG-CoA reductase (HMGCR) inhibition and exogenous nitric oxide (NO) release. NO-Pravastatin activates PPARα/γ and ABCA1, and inhibits LPS (HY-D1056)-induced TNFα production. NO-Pravastatin can be used in research related to gallstones and cardiovascular diseases.

For research use only. We do not sell to patients.

NO-Pravastatin

NO-Pravastatin Chemical Structure

CAS No. : 733034-46-3

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NO-Pravastatin Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

NO-Pravastatin is a derivative of Pravastatin (HY-B0165) covalently linked with an NO donor moiety, endowing it with dual functions of HMG-CoA reductase (HMGCR) inhibition and exogenous nitric oxide (NO) release. NO-Pravastatin activates PPARα/γ and ABCA1, and inhibits LPS (HY-D1056)-induced TNFα production. NO-Pravastatin can be used in research related to gallstones and cardiovascular diseases[1][2].

IC50 & Target[2]

PPARα

 

PPARγ

 

In Vitro

NO-pravastatin (15 μM; 18-24 h) significantly upregulates the expression of ABCA1 and LXRα in cultured canine gallbladder epithelial cells, and inhibits LPS-induced TNFα production in the same cell type[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NO-Pravastatin Related Antibodies

Western Blot Analysis[1]

Cell Line: cultured canine gallbladder epithelial cells (GBEC)
Concentration: 15 μM
Incubation Time: 24 h
Result: Significantly increased PPARα protein expression relative to the no-treatment control, at a level similar to the PPARα agonist WY-14643.
Significantly increased PPARγ protein expression relative to the no-treatment control, with a stronger activation effect than simvastatin.
Significantly increased ABCA1 protein expression relative to the no-treatment control, though this induction was less potent than that of PPARα or PPARγ ligands.

RT-PCR[1]

Cell Line: cultured canine gallbladder epithelial cells (GBEC)
Concentration: 15 μM (ABCA1 and LXRα mRNA analysis); 15 μM (TNFα mRNA analysis)
Incubation Time: 24 h (ABCA1 and LXRα mRNA analysis); 18 h pre-treatment prior to 1 h LPS loading (TNFα mRNA analysis)
Result: Significantly increased ABCA1 mRNA expression relative to the no-treatment control, though this induction was less potent than that of PPARα or PPARγ ligands.
Significantly increased LXRα mRNA expression relative to the no-treatment control.
Almost completely repressed LPS-induced TNFα mRNA production relative to the LPS-only treatment group; simultaneous treatment with NO-pravastatin and LPS did not show this suppressive effect.
Molecular Weight

541.63

Formula

C27H43NO10
CAS No.
SMILES

CC[C@H](C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC(OCCCCO[N+]([O-])=O)=O)C)=C[C@H](C1)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NO-Pravastatin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NO-Pravastatin733034-46-3Drug DerivativeHMG-CoA Reductase (HMGCR)PPARATP-binding cassette (ABC) transportersTNF ReceptorDrug derivativePeroxisome proliferator-activated receptorsATP-binding cassette transportersTumor Necrosis Factor ReceptorTNFRPPARαgallbladder epithelial cellscanine gallbladder epithelial cellsLXRαABCA1gallstoneslipopolysaccharidePPARγTNFαInhibitorinhibitorinhibit

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