733034-46-3
Chemical Structure
NO-Pravastatin
- CAS No.: 733034-46-3
- Formula:C27H43NO10
- Molecular Weight:541.63
IUPAC Name: 4-(nitrooxy)butyl (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
InChIKey: BYXWQFNMLQKHSM-DCOASORXSA-N
SMILES: CC[C@H](C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC(OCCCCO[N+]([O-])=O)=O)C)=C[C@H](C1)O)=O
Biological Activity: NO-Pravastatin is a derivative of Pravastatin (HY-B0165) covalently linked with an NO donor moiety, endowing it with dual functions of HMG-CoA reductase (HMGCR) inhibition and exogenous nitric oxide (NO) release. NO-Pravastatin activates PPARα/γ and ABCA1, and inhibits LPS (HY-D1056)-induced TNFα production. NO-Pravastatin can be used in research related to gallstones and cardiovascular diseases[1][2].
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NO-Pravastatin | NO-Pravastatin is a derivative of Pravastatin (HY-B0165) covalently linked with an NO donor moiety, endowing it with dual functions of HMG-CoA reductase (HMGCR) inhibition and exogenous nitric oxide (NO) release. NO-Pravastatin activates PPARα/γ and ABCA1, and inhibits LPS (HY-D1056)-induced TNFα production. NO-Pravastatin can be used in research related to gallstones and cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Lee J, et al. HMG-CoA reductase inhibitors (statins) activate expression of PPARalpha/PPARgamma and ABCA1 in cultured gallbladder epithelial cells. Digestive diseases and sciences. 2010 Feb;55(2):292-9. [Content Brief]
- [2]. Seymour K, et al. Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis. Vascular and endovascular surgery. 2014;48(7-8):470-5. [Content Brief]
