1. NF-κB
    Apoptosis
  2. NF-κB
    TNF Receptor
    IKK
  3. Verproside

Verproside 

Cat. No.: HY-126232
Handling Instructions

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo.

For research use only. We do not sell to patients.

Verproside Chemical Structure

Verproside Chemical Structure

CAS No. : 50932-20-2

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Description

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1].

IC50 & Target[1]

NF-κB

 

TNF-α

 

IKK

 

In Vitro

Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1].

Western Blot Analysis[1]

Cell Line: NCI-H292 cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 2 hours
Result: Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1.
In Vivo

Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2].

Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2]
Dosage: 30 mg/kg
Administration: Intragastrically; 48 hours
Result: Reduced significantly the immunoglobulin E (IgE) levels.
Molecular Weight

498.43

Formula

C₂₂H₂₆O₁₃

CAS No.

50932-20-2

SMILES
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Verproside
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