GPER activator 1
GPER activator 1 (compound 6-26) is a GPER-selective compound without cytotoxicity. GPER activator 1 exhibits dual inhibition of TNFα- and IL-6-induced inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2629960-35-4
- Formula: C17H14ClFN2O2S
- Molecular Weight:364.82
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
0.23 μM
Compound: 6-26
|
Inhibition of TNFalpha induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with TNFalpha stimulation for 3 hrs by fluorescence based microplate reader assay
Inhibition of TNFalpha induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with TNFalpha stimulation for 3 hrs by fluorescence based microplate reader assay
|
[PMID: 38896548] |
| U-937 | IC50 |
0.35 μM
Compound: 6-26
|
Inhibition of IL6 induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with IL6 stimulation for 3 hrs by fluorescence based microplate reader assay
Inhibition of IL6 induced adhesion of TPA treated human U-937 cells to human HT-29 cells pretreated with HT-29 for 1 hr followed by U-937 addition along with IL6 stimulation for 3 hrs by fluorescence based microplate reader assay
|
[PMID: 38896548] |
Chemical Information
-
CAS No. 2629960-35-4
-
Molecular Weight 364.82
-
Formula C17H14ClFN2O2S
-
SMILES
CC1=C(C(C)=C(C(NC(C2=C(C3=C(S2)C=C(F)C=C3)Cl)=O)=N1)C)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)