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Cat. No.: HY-W753956

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Iminostilbene-d₁₀

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases.

For research use only. We do not sell to patients.

CAS No.: 3044090-39-0
Formula: C₁₄HD₁₀N
Molecular Weight:203.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (249 KB)

Iminostilbene-d₁₀ Chemical Structure

CAS No.: 3044090-39-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All COX Isoforms :

All HIF/HIF Prolyl-Hydroxylase Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All STAT Isoforms :

All NO Synthase Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 3044090-39-0
Unlabeled Cas 256-96-2
Molecular Weight 203.31
Formula C₁₄HD₁₀N
SMILES

[2H]C1=C(C2=C(NC3=C1C([2H])=C(C([2H])=C3[2H])[2H])C([2H])=C([2H])C([2H])=C2[2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.