TNFR1-IN-2
TNFR1-IN-2 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signal transduction, with an IC50 value of 2.8 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases.
For research use only. We do not sell to patients.
- CAS No.: 3053449-34-3
- Formula: C104H124ClN21O22S
- Molecular Weight:2087.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TNFR1 0.1 nM (Kd) |
TNFR2 >1000 nM (Kd) |
TNFR1-IN-2 (Seq ID NO.183) inhibits TNFR1, with a Kd of 0.1 nM for hTNFR1 and a Kd of >1000 nM for hTNFR2[1].
TNFR1-IN-2 (preincubated for 1 h, then co-incubated with TNFα for 16-18 h) inhibits TNFα-induced NF-κB signaling in THP-1 cells, with an IC50 value of 2.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3053449-34-3
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Molecular Weight 2087.74
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Formula C104H124ClN21O22S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNFR1-IN-2 Related Classifications
HY-P11834 Related Classifications
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