3053449-34-3
Chemical Structure
TNFR1-IN-2
- CAS No.: 3053449-34-3
- Formula:C104H124ClN21O22S
- Molecular Weight:2087.74
InChIKey: KQHXXPQWKZQWDI-SGQKSKNDSA-N
SMILES: C[C@H]([C@@]1([H])C(N[C@@H](CSCC(N[C@H](C(N[C@H](C(N2[C@](COC(C)(C2)C)([H])C(N[C@H](C(N([C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@](C)(C(N[C@H](C(N[C@H](C(N(CC(N1)=O)C)=O)CC3=CC=C(C=C3)O)=O)CC4=CC=C(C=C4)C(O)=O)=O)CO)=O)CC(C5=CC=C6)=CNC5=C6Cl)=O)CC7=CC=NC=C7)=O)CC(N)=O)=O)C)CC)=O)CC8=CNC9=CC=CC=C89)=O)=O)CC%10=CC=NC=C%10)=O)CCCC)=O)C(N)=O)=O)C(C%11=CC=C%12)=CNC%11=C%12OC
Biological Activity: TNFR1-IN-2 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signal transduction, with an IC50 value of 2.8 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases[1].
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TNFR1-IN-2 | TNFR1-IN-2 is a selective TNFR1 inhibitor with a Kd of 0.1 nM for hTNFR1. TNFR1-IN-1 inhibits TNFα-induced NF-κB signal transduction, with an IC50 value of 2.8 nM. TNFR1-IN-1 can be used in research related to inflammatory and immune diseases. | |||||||||||||||||||||
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