Cobra Venom Factor  (Synonyms: CVF)

Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.)^[1][2][3].

Cobra Venom Factor (1 μM; 24 hours) incubated with human factor B, factor D, and Mg²⁺ activates factor B and cleaves it into Ba and Bb fragments^[3].
Cobra Venom Factor incubated with guinea pig serum and guinea pig erythrocytes induces bystander hemolysis^[3].
Cobra Venom Factor incubated with guinea pig serum consumes serum complement activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

Colorless to light yellow

[Cobra Venom Factor]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lu Z, et al. Nerve growth factor from Chinese cobra venom stimulates chondrogenic differentiation of mesenchymal stem cells. Cell Death Dis. 2017 May 18;8(5):e2801.  [Content Brief]

  [2]. Proctor LM, et al. Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. Int Immunopharmacol. 2006 Aug;6(8):1224-32.  [Content Brief]

  [3]. Kock MA, et al. Structure and function of recombinant cobra venom factor. J Biol Chem. 2004 Jul 16;279(29):30836-43.  [Content Brief]