Vitedoamine A
Vitedoamine A is a Phenylnaphthalene-type lignan alkaloid. Vitedoamine A can be isolated from Vitex negundo. Vitedoamine A inhibits the activity of IKKβ with an IC50 value of 39 μM. Vitedoamine A could inhibit the transcriptional activity of NF-κB, and suppress the production of NO and reduce the expressions of inflammatory cytokines (IL-1β, IL-6, and TNF-α). Vitedoamine A inhibits the phosphorylation of IKKα/β and p65, and prevents the degradation of IκBα. Vitedoamine A possesses anti-rheumatoid arthritis capacity.
For research use only. We do not sell to patients.
- CAS No.: 819861-41-1
- Formula: C20H17NO5
- Molecular Weight:351.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IKKβ 39 μM (IC50) |
IKK-α |
IL-6 |
IL-1β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
1.53 μM
Compound: 8
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method
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[PMID: 19715321] |
Vitedoamine A (5-60 μM) directly targets IKKβ and inhibits its enzymatic activity, with an IC50 of 39 μM[1].
Vitedoamine A (1-80 μM; 48 h for cell viability assay) dose-dependently inhibits NF-κB transcriptional activity in TNF-α-stimulated 293 T cells without reducing cell viability[1].
Vitedoamine A (1-40 μM; 4 h) inhibits the activation of NF-κB by suppressing LPS/TNF-α-induced phosphorylation of IKKα/β in RAW264.7 cells[1].
Vitedoamine A (1-40 μM; 4 h) exerts anti-rheumatoid arthritis (RA) activity in IL-1β-stimulated human fibroblast-like synoviocytes by targeting IKKβ to inhibit NF-κB pathway activation and reduce the production of proinflammatory cytokines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS/TNF-α-induced RAW264.7 cells
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Concentration:1, 10, 20, 40 μM
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Incubation Time:4 h
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Result:Decreased LPS-induced expression of p-p65 and inhibited LPS-induced degradation of IκB; Inhibited the expression of p-IKKα/β, but had not effects on the expressions on IKKα and IKKβ; Had no effect on p-TAK1 expression induced by LPS; Decreased TNF-α-induced p-IKK expression level, and inhibited p-p65 expression level and IκB degradation.
Chemical Information
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CAS No. 819861-41-1
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Molecular Weight 351.35
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Formula C20H17NO5
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SMILES
O=C1NCC2=C1C=C3C=C(C(O)=CC3=C2C4=CC(OC)=C(O)C=C4)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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