2. GPCR/G Protein Immunology/Inflammation Apoptosis
  3. Leukotriene Receptor Interleukin Related TNF Receptor NO Synthase
  4. 2-ARA-LysoPtdEtn

2-ARA-LysoPtdEtn  (Synonyms: 1-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamine)

Cat. No.: HY-185709
Handling Instructions Technical Support

2-ARA-LysoPtdEtn (1-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamine) is an orally active polyunsaturated acyl lysophosphatidylethanolamine. 2-ARA-LysoPtdEtn diminishes formation of LTC4, LTB4, and 12-HETE. 2-ARA-LysoPtdEtn lowers levels of IL-1β, IL-6, TNF-α, and NO. 2-ARA-LysoPtdEtn augments IL-10 levels and upgrades formation of 15-HETE and LXA4. 2-ARA-LysoPtdEtn can be used for the research of peritonitis.

For research use only. We do not sell to patients.

2-ARA-LysoPtdEtn

2-ARA-LysoPtdEtn Chemical Structure

CAS No. : 53847-31-7

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2-ARA-LysoPtdEtn Related Antibodies

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nNOS iNOS eNOS

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Description

2-ARA-LysoPtdEtn (1-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamine) is an orally active polyunsaturated acyl lysophosphatidylethanolamine. 2-ARA-LysoPtdEtn diminishes formation of LTC4, LTB4, and 12-HETE. 2-ARA-LysoPtdEtn lowers levels of IL-1β, IL-6, TNF-α, and NO. 2-ARA-LysoPtdEtn augments IL-10 levels and upgrades formation of 15-HETE and LXA4. 2-ARA-LysoPtdEtn can be used for the research of peritonitis[1].

IC50 & Target[1]

IL-1β

 

IL-6

 

LTC4

 

IL-10

 

In Vitro

2-ARA-LysoPtdEtn (0-20 μM) acts as an effective substrate for Glycine max LOX-1B, porcine leukocyte 12/15-LOX, and human recombinant 15-LOX-2, with catalytic efficacy values of 10.9, 10.3, and 14.8 units/mg/μM, respectively[1].
2-ARA-LysoPtdEtn (100 μM; 30 min) is effectively converted by Glycine max LOX-1B into its 15-hydroperoxy derivative, 2-(15-HpETE)-lysoPtdEtn, as identified via LC/ESI-MS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-ARA-LysoPtdEtn Related Antibodies
In Vivo

2-ARA-lysoPtdEtn (15-150 µg/kg; p.o.; single dose) dose-dependently inhibits Zymosan A (HY-W250113)-induced peritonitis in ICR mice with an ED50 of 221 µg/kg for plasma leakage inhibition and 123 µg/kg for leukocyte infiltration inhibition, while also promoting inflammation resolution[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (4-6 weeks of age, 29-30 g body weight, intraperitoneal injected 1 mg Zymosan A to establish a eritonitis model)[1]
Dosage: 15 µg/kg; 50 µg/kg; 150 µg/kg
Administration: p.o.; single dose
Result: Suppressed Zymosan A-induced plasma leakage by 17% at 50 µg/kg and by 36% at 150 µg/kg; ED50 for plasma leakage inhibition was 221 µg/kg.
Decreased total leukocyte infiltration by 56% at 150 µg/kg; ED50 for leukocyte infiltration inhibition was 123 µg/kg.
Dose-dependently reduced Zymosan A-induced formation of LTC4 (ED50 = 132 µg/kg), LTB4 (ED50 = 139 µg/kg), and 12-HETE.
Dose-dependently reduced Zymosan A-induced levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6; increased anti-inflammatory cytokine IL-10 levels by approximately five-fold at 150 µg/kg compared to the Zymosan A-challenged group.
Diminished Zymosan A-induced nitric oxide production by 60% at 50 µg/kg and by 70% at 150 µg/kg.
Dose-dependently increased peritoneal levels of 15-HETE (3.5-fold at 15 µg/kg, 5-fold at 50 µg/kg, 9-fold at 150 µg/kg) and LXA4 (2-fold at 15 µg/kg, 4-fold at 50 µg/kg, 5.5-fold at 150 µg/kg) compared to the Zymosan A-challenged group.
Reduced total leukocyte infiltration by ~23% at 15 hours, ~21% at 20 hours, and ~33% at 24 hours when administered 12 hours after Zymosan A treatment compared to the Zymosan A-alone group.
Molecular Weight

501.59

Formula

C25H44NO7P
CAS No.
SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@H](CO)COP(OCCN)(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-ARA-LysoPtdEtn Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-ARA-LysoPtdEtn53847-31-71-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamineLeukotriene ReceptorInterleukin RelatedTNF ReceptorNO SynthaseILTumor Necrosis Factor ReceptorTNFRNitric oxide synthasesNOS12-HETEzymosan A-induced peritonitisleukocyte extravasationleukocyte infiltrationIL-1βTNF-αLTC4miceIL-6LTB4Inhibitorinhibitorinhibit

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