TNF-α-IN-28
TNF-α-IN-28 (compound 4ea) is a TNF-α and NF-κB inhibitor with anti-inflammatory activity. TNF-α-IN-28 inhibits TNF-α and NF-κB expression. TNF-α-IN-28 interacts with TNF-α dimer.
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- CAS No.: 3118012-34-0
- Formule: C20H21NO7
- Masse moléculaire:387.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
TNF-α-IN-28 (compound 4ea) (1-30 μM) potently inhibits LPS-induced TNF-α expression in RAW 264.7 macrophage cells with an IC50 of 6.297 μM[1].
TNF-α-IN-28 (30 μM) prevents NF-κB nuclear translocation in LPS-stimulated RAW 264.7 macrophage cells, suppressing NF-κB activation[1].
TNF-α-IN-28 binds stably to the dimeric interface of TNF-α (PDB ID: 2AZ5) with an average binding affinity of -8.02 Kcal/mol, forming key interactions with residues critical for TNF-α inhibition[1].
TNF-α-IN-28 stabilizes the structure of TNF-α (PDB ID: 2AZ5) over a 500 ns molecular dynamics simulation, maintaining a stable binding conformation and forming persistent interactions with residues critical for TNF-α function[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3118012-34-0
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Masse moléculaire 387.38
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Formule C20H21NO7
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SMILES
O=C(N1CCOCC1)OC2=CC(OC(C=C3C)=O)=C3C=C2/C=C/C(OCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNF-α-IN-28 Related Classifications
HY-182006 Related Classifications
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