country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182308

Copy Link Print Information

LC-PDA-01

LC-PDA-01 is a selective peroxiredoxin 1 (PRDX1) activator with an EC₅₀ of 111.8 nM and a human K_D of 123.2 nM. LC-PDA-01 inhibits the expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. LC-PDA-01 can be used in antioxidant/anti-inflammatory research.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₅Cl₂N₅O₄
Molecular Weight:436.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LC-PDA-01 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

In Vitro

LC-PDA-01 (100 μM; 3 h) significantly stabilizes endogenous PRDX1 protein in HEK-293T human embryonic kidney cells, as measured by cellular thermal shift assay^[1].
LC-PDA-01 (20 μM) significantly suppresses LPS (HY-D1056)-induced expression of IL-1β, IL-6, and TNF-α mRNA in RAW 264.7 mouse macrophages^[1].
LC-PDA-01 (Incubated to measure half-life of 381.6 min) shows excellent metabolic stability in mouse liver microsomes, with a half-life of 381.6 min and a hepatic extraction ratio of 13.7%^[1].
LC-PDA-01 has low apparent permeability (Papp A→B = 0.06 × 10^-6 cm/s) across Caco-2 monolayers, with a high efflux ratio of 5.23, suggesting potential P-gp-mediated active efflux^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 436.25
Formula C₁₈H₁₅Cl₂N₅O₄
SMILES

NC1=CC=C(C=C1)C[C@H](C(O)=O)NC(C2=CN(N=N2)C3=CC(Cl)=CC(Cl)=C3O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhu YY, et al. Design and evaluation of peroxiredoxin 1 agonist based on scaffold hopping of salvianolic acids and combinatorial click chemistry. Acta Pharmacol Sin. 2026 Mar 9.
[Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

LC-PDA-01

All Interleukin Related Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LC-PDA-01 Related Classifications

HY-182308 Related Classifications