Cat. No.: HY-N2464

Maltotetraose

(Synonyms: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 34612-38-9
Formula: C₂₄H₄₂O₂₁
Molecular Weight:666.58

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Maltotetraose Chemical Structure

CAS No.: 34612-38-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All TNF Receptor Isoforms :

All Endogenous Metabolite Isoforms :

All Integrin Isoforms :

All NF-κB Isoforms :

In Vitro

Maltotetraose (20-40 μM, 30 min) suppresses NF-κB activation and ICAM-1 expression, potentially aiding in the early prevention of atherosclerosis^[2].
Maltotetraose (20 μM, 30 min) inhibits PDGF-induced vascular smooth muscle cell migration, suggesting a potential role in atherosclerosis prevention^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

MOVAS-1 mouse vascular smooth muscle cells
Concentration:

20-40 μM
Incubation Time:

30 min (Cells were pretreated with Maltotetraose (20-40 μM) for 30 minutes, followed by TNF-α (10 ng/mL) stimulation for 3-8 hours)
Result:

Inhibited the phosphorylation of NF-κB-related protein.

RT-PCR^[2]

Cell Line:

MOVAS-1 mouse vascular smooth muscle cells
Concentration:

20-40 μM
Incubation Time:

30 min (Cells were pretreated with Maltotetraose (20-40 μM) for 30 minutes, followed by TNF-α (10 ng/mL) stimulation for 3-8 hours)
Result:

Significantly decreased ICAM-1 mRNA levels.

Cell Migration Assay ^[2]

Cell Line:

MOVAS-1 mouse vascular smooth muscle cells
Concentration:

20 μM
Incubation Time:

30 min (Cells were pretreated with Maltotetraose (20 μM) for 30 minutes, followed by PDGF (20 ng/mL) stimulation for 6-7 days)
Result:

Significantly inhibited PDGF-induced vascular smooth muscle cell migration and new blood vessel formation in aortic ring explants.

In Vivo

Maltotetraose (10% in diet or 5,000 mg/kg via p.o., once daily for 90 days) dose not induce significant toxicity, suggesting good long-term safety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats^[3]
Dosage:

Dietary group: 10% (equivalent to 6,818 mg/kg/day in males, 7,464 mg/kg/day in females); Gavage group: 1,000, 3,000, or 5,000 mg/kg/day
Administration:

Dietary intake or oral gavage (p.o.), Once daily for 90 consecutive days
Result:

Sid not cause mortality or severe adverse effects in rats over 90 days.
Reduced food intake but no significant body weight differences (The 5,000 mg/kg/day gavage group).

Chemical Information

CAS No. 34612-38-9
Appearance Solid
Molecular Weight 666.58
Formula C₂₄H₄₂O₂₁
Color White to off-white
SMILES

OC[C@@H](O[C@H](O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)[C@H](O)[C@H]1O)[C@@]1([H])O[C@H]2O[C@@H]([C@@H](O[C@@]3([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO
Synonyms

Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

J Agric Food Chem

Structural Stabilization and Activity Enhancement of Glucoamylase via the Machine-Learning Technique and Immobilization. [Abstract]

2025 Mar 26;73(12):7347-7363. PMID: 40080106

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (187.52 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5002 mL

7.5010 mL

15.0019 mL

5 mM

0.3000 mL

1.5002 mL

3.0004 mL

10 mM

0.1500 mL

0.7501 mL

1.5002 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (150.02 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Whitlow KJ, et al. Maltotetraose as a substrate for enzyme-coupled assay of amylase activity in serum and urine. Clin Chem. 1979 Mar;25(3):481-3. [Content Brief]

[2]. Shin SY, et al. Inhibition of PDGF-induced migration and TNF-α-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells. Mol Nutr Food Res. 2016 Sep;60(9):2086-97. [Content Brief]

[3]. Matsumoto S, et al. Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats[J]. Fundamental Toxicological Sciences, 2020, 7(3): 141-152.

[4]. Zlitni A, et al. Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections. Nat Commun. 2020 Mar 6;11(1):1250. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5002 mL	7.5010 mL	15.0019 mL	37.5049 mL
	5 mM	0.3000 mL	1.5002 mL	3.0004 mL	7.5010 mL
	10 mM	0.1500 mL	0.7501 mL	1.5002 mL	3.7505 mL
	15 mM	0.1000 mL	0.5001 mL	1.0001 mL	2.5003 mL
	20 mM	0.0750 mL	0.3750 mL	0.7501 mL	1.8752 mL
	25 mM	0.0600 mL	0.3000 mL	0.6001 mL	1.5002 mL
	30 mM	0.0500 mL	0.2500 mL	0.5001 mL	1.2502 mL
	40 mM	0.0375 mL	0.1875 mL	0.3750 mL	0.9376 mL
	50 mM	0.0300 mL	0.1500 mL	0.3000 mL	0.7501 mL
	60 mM	0.0250 mL	0.1250 mL	0.2500 mL	0.6251 mL
	80 mM	0.0188 mL	0.0938 mL	0.1875 mL	0.4688 mL
	100 mM	0.0150 mL	0.0750 mL	0.1500 mL	0.3750 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Maltotetraose

1 Cited Publications

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Maltotetraose

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Publications Citing Use of MedChemExpress (MCE) Maltotetraose

All TNF Receptor Isoforms

All Endogenous Metabolite Isoforms

All Integrin Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Maltotetraose Related Classifications