2. Immunology/Inflammation
  3. Interleukin Related
  4. JTE-607 free base

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base.

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CAS No. : 188791-71-1

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JTE-607 free base Related Antibodies

Top Publications Citing Use of Products

    JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487.  [Abstract]

    Flow cytometry analysis of HeLa cells without (-) or with the indicated concentrations of JTE-607 (500 nM) and adavosertib (AZD1775) for 24 h. Numbers indicate γH2AX-positive cells.

    JTE-607 free base purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 22;54(3):gkaf1487.  [Abstract]

    Flow cytometry analysis of pRNAPII S2 levels on chromatin in HeLa cells without (-) or with 1 μM JTE-607 for 2, 6, and 24 h (orange color).

    JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32.  [Abstract]

    JTE-607 (7.143 μg per day per mouse; ICV) NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.

    JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32.  [Abstract]

    JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice suppressed tumor growth and prolonged mouse survival.

    JTE-607 free base purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Mar 19;10(1):32.  [Abstract]

    JTE-607 (7.143 μg per day per mouse; ICV) in NSG immunocompromised mice induced tumor cell apoptosis, as measured by the TUNEL assay.

    View All Interleukin Related Isoform Specific Products:

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    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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    Description

    JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base[2].

    Molecular Weight

    524.44

    Formula

    C25H31Cl2N3O5
    CAS No.
    SMILES

    O=C([C@@H](NC(C1=CC(Cl)=C(C(Cl)=C1O)OCCN2CCN(CC2)C)=O)CC3=CC=CC=C3)OCC
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    JTE-607 free base Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JTE-607188791-71-1JTE607JTE 607Interleukin RelatedILInflammatoryCytokineInhibitorAnti-inflammatoryImmunosuppressionendotoxinTNF-αIL-1βIL-6IL-8IL-10CPSF3inhibitorinhibit

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