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Art. -Nr.: HY-184709

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COX-2-IN-68

COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC₅₀ of 0.82 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces the serum levels of PGE₂, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw edema model. COX-2-IN-69 can be used in inflammation-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₁H₁₉BrN₂O₃
Molecular Weight:427.29

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-68 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

COX-2

0.82 μM (IC₅₀)

IL-1β

Alle COX Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

COX-2-IN-68 (Compound 4e) (10 mg/kg; p.o.; single administration) exhibits potent in vivo anti-inflammatory activity in a rat paw edema model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Produced edema percentages of 17.58% at 1 h, 14.22% at 2 h, and 13.89% at 3 h post-Carrageenan injection.
Reduced serum PGE2 levels by 61.48% compared to the Carrageenan control group.
Reduced serum IL-1β levels by 62.17% compared to the carrageenan control group.
Reduced serum TNF-α levels by 58.36% compared to the carrageenan control group.
Showed moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands, with milder gastric effects than indomethacin.

Chemical Information

Molecular Weight 427.29
Formel C₂₁H₁₉BrN₂O₃
SMILES

CCOC1=C(O)C=CC(/C=C/C2=NNC(C(CC3=CC=C(Br)C=C3)=C2)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Elbahrawy AH, et al. Design, synthesis, biological evaluation and histopathological studies of Pyridazine and Pyrazoline derivatives as potential anti-inflammatory agents. Bioorganic chemistry. 2026 Jun 24;180:110164. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
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COX-2-IN-68

Alle COX Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

COX-2-IN-68 Related Classifications

HY-184709 Related Classifications