p38-α MAPK-IN-9
p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor (Ki: 0.057 nM). p38-α MAPK-IN-9 inhibits LPS (HY-D1056) induced TNFα production in hPBMCs (IC50: 18 nM).
For research use only. We do not sell to patients.
- CAS No.: 868272-50-8
- Formula: C19H20N8O2
- Molecular Weight:392.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
18 μM
Compound: 25a
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Concentration required to inhibit LPS-induced TNFalpha production in human peripheral blood mononuclear cells; n=3
Concentration required to inhibit LPS-induced TNFalpha production in human peripheral blood mononuclear cells; n=3
|
[PMID: 16190753] |
Chemical Information
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CAS No. 868272-50-8
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Molecular Weight 392.41
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Formula C19H20N8O2
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SMILES
N#CC1=C(NC(C)C)N=C(N)N=C1NC2=CC(C(NC3=NOC=C3)=O)=CC=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)