Heveadride
Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 39595-41-0
- 화학식: C18H20O6
- 분자량:332.35
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
제품 설명
In Vitro
Heveadride (Compound 2) (5 and 10 μg/disc) shows moderate inhibitory activity against filamentous fungi, and has no activity against yeast at a concentration of 5 μg/disc, while has weak activity against some yeast species at a concentration of 100 μg/disc[1].
Heveadride (Compound 4) (10-100 μM, 2 h) demonstrates dose-dependent inhibitory activity against TNFα-induced NF-κB in K562 cells[2].
Heveadride (0.1-100 μM, 8-72 h) does not significantly decrease K562 cell viability at any concentration or measured time point but reduces K562 proliferation at 100 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 39595-41-0
-
분자량 332.35
-
화학식 C18H20O6
-
SMILES
CCC[C@@H]1C2=C(C(OC2=O)=O)CCC3=C(C(OC3=O)=O)C[C@H]1CC
-
Structure Classification
-
Initial Source
Helmin thosporium heveae
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
-
Data Sheet (277 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hosoe T, et al. A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672. J Antibiot (Tokyo). 2004 Sep;57(9):573-8. [Content Brief]
[2]. Harms H, et al. Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential. Mar Drugs. 2015 Aug 6;13(8):4949-66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heveadride Related Classifications
HY-N15653 Related Classifications
Powered by Bioz