Heveadride
Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM.
For research use only. We do not sell to patients.
- CAS No.: 39595-41-0
- Formula: C18H20O6
- Molecular Weight:332.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Heveadride (Compound 2) (5 and 10 μg/disc) shows moderate inhibitory activity against filamentous fungi, and has no activity against yeast at a concentration of 5 μg/disc, while has weak activity against some yeast species at a concentration of 100 μg/disc[1].
Heveadride (Compound 4) (10-100 μM, 2 h) demonstrates dose-dependent inhibitory activity against TNFα-induced NF-κB in K562 cells[2].
Heveadride (0.1-100 μM, 8-72 h) does not significantly decrease K562 cell viability at any concentration or measured time point but reduces K562 proliferation at 100 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 39595-41-0
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Molecular Weight 332.35
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Formula C18H20O6
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SMILES
CCC[C@@H]1C2=C(C(OC2=O)=O)CCC3=C(C(OC3=O)=O)C[C@H]1CC
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Structure Classification
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Initial Source
Helmin thosporium heveae
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hosoe T, et al. A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672. J Antibiot (Tokyo). 2004 Sep;57(9):573-8. [Content Brief]
[2]. Harms H, et al. Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential. Mar Drugs. 2015 Aug 6;13(8):4949-66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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