PF-06940434
PF-06940434 (ADWA-11) is a monoclonal antibody targeting integrin αvβ8. PF-06940434 inhibits αvβ8-mediated TGF-β activation. PF-06940434 increases the accumulation of tumor-infiltrating CD8+ T cells and upregulates the expression of granzyme B and TNF-γ. PF-06940434 blocks the inhibitory effect of CD4+CD25+ T cells on the cytotoxic activity of tumor CD8+ T cells. PF-06940434 enhances the anti-tumor efficacy of combination therapies with other immunomodulators or radiotherapy and induces long-term anti-tumor immunity. PF-06940434 can be used in the research of squamous cell carcinoma, breast cancer, colon cancer, and prostate adenocarcinoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform TNF Receptor
More
Activité biologique
Description
IC50 & Target
[1]|
αvβ8 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-06940434 (10 mg/kg; i.p.; days 0 and 7) monotherapy induces complete tumor regression in 10% of mice with mammary carcinoma, enhances intratumoral CD8+ T cell cytotoxic function, inhibits TGF-β signaling, and elicits long-term anti-tumor immunity[1].
PF-06940434 (10 mg/kg; i.p.; days 0 and 7) monotherapy potently inhibits prostate adenocarcinoma tumor growth, increases intratumoral CD8+ T cell accumulation and cytotoxic gene expression, and inhibits TGF-β signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:FVB/NJ (equal numbers of male and female; subcutaneous injection of 1.5×104 CCK168 cells to induce squamous cell carcinoma)[1]
-
Dosage:10 mg/kg
-
Administration:i.p.; days 0 and 7
-
Result:Induced tumor regression in most mice, with 4 of 10 mice showing complete tumor regression.
Significantly increased the percentage of intratumoral CD8+ T cells, the percentage of CD8+ T cells expressing granzyme B, and the percentage of CD4+ and CD8+ T cells expressing interferon-γ (IFNγ).
Significantly reduced SMAD3 phosphorylation (pSMAD3) in whole-tumor lysates.
Significantly upregulated mRNA expression of granzyme B, IFNγ, and Fas ligand in intratumoral CD8+ T cells.
Prevented tumor formation in re-challenged mice, indicating long-term anti-tumor immunity.
-
Animal Model:BALB/c (female; orthotopic injection of 5×104 EMT6 cells into the fourth mammary fat pad to induce mammary carcinoma)[1]
-
Dosage:10 mg/kg
-
Administration:i.p.; days 0 and 7
-
Result:Induced complete tumor regression in 2 of 20 mice.
Significantly increased the percentage of intratumoral CD8+ T cells, the percentage of CD8+ T cells expressing granzyme B, and the percentage of CD4+ and CD8+ T cells expressing IFNγ.
Significantly reduced pSMAD3 in whole-tumor lysates.
Significantly upregulated mRNA expression of granzyme B, IFNγ, granzyme A, and Fas ligand in intratumoral CD8+ T cells.
Prevented tumor formation in re-challenged mice, indicating long-term anti-tumor immunity.
-
Animal Model:C57BL/6J (male; subcutaneous injection of 1×106 TRAMPC2 cells with matrigel to induce prostate adenocarcinoma)[1]
-
Dosage:10 mg/kg
-
Administration:i.p.; days 0 and 7
-
Result:Markedly reduced tumor growth.
Significantly increased the percentage of intratumoral CD8+ T cells, the percentage of CD8+ T cells expressing granzyme B, and the percentage of CD4+ and CD8+ T cells expressing IFNγ.
Significantly reduced pSMAD3 in whole-tumor lysates.
Significantly upregulated mRNA expression of granzyme B, IFNγ, granzyme A, and Fas ligand in intratumoral CD8+ T cells.
-
Animal Model:C57BL/6J (male, Itgb8-f/f littermates; subcutaneous injection of 1×106 TRAMPC2 cells with matrigel to induce prostate adenocarcinoma)[1]
-
Dosage:10 mg/kg
-
Administration:i.p.; days 0 and 7
-
Result:Significantly inhibited tumor growth and enhanced survival in Itgb8-f/f littermates.
Showed no additional benefit in CD4-Cre;Itgb8-f/f mice (with T cell-specific Itgb8 deletion).
Chemical Information
-
SMILES
[PF-06940434]
-
Synonyms
ADWA-11
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-06940434 Related Classifications
HY-P992519 Related Classifications
Powered by Bioz
Keywords
- PF-06940434
- ADWA-11
- PF06940434
- PF 06940434
- ADWA11
- ADWA 11
- Integrin
- TNF Receptor
- TGF-β Receptor
- Tumor Necrosis Factor Receptor
- TNFR
- Transforming growth factor beta receptors
- Smad3
- mammary cancer
- colon cancer
- transforming growth factor β
- integrin αvβ8
- prostate cancer
- SNB229 human glioblastoma cells
- CD8+ T cells
- squamous cell carcinoma
- SNB19 human glioblastoma cells
- Inhibitor
- inhibitor
- inhibit