aPKC-IN-2
Based on 1 Customer Validation
aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 15854-08-7
- Formula: C14H15NO2S
- Molecular Weight:261.34
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 15854-08-7
-
Appearance Solid
-
Molecular Weight 261.34
-
Formula C14H15NO2S
-
Color Off-white to light yellow
-
SMILES
O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (239.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8264 mL | 19.1322 mL | 38.2643 mL | 95.6608 mL |
| 5 mM | 0.7653 mL | 3.8264 mL | 7.6529 mL | 19.1322 mL | |
| 10 mM | 0.3826 mL | 1.9132 mL | 3.8264 mL | 9.5661 mL | |
| 15 mM | 0.2551 mL | 1.2755 mL | 2.5510 mL | 6.3774 mL | |
| 20 mM | 0.1913 mL | 0.9566 mL | 1.9132 mL | 4.7830 mL | |
| 25 mM | 0.1531 mL | 0.7653 mL | 1.5306 mL | 3.8264 mL | |
| 30 mM | 0.1275 mL | 0.6377 mL | 1.2755 mL | 3.1887 mL | |
| 40 mM | 0.0957 mL | 0.4783 mL | 0.9566 mL | 2.3915 mL | |
| 50 mM | 0.0765 mL | 0.3826 mL | 0.7653 mL | 1.9132 mL | |
| 60 mM | 0.0638 mL | 0.3189 mL | 0.6377 mL | 1.5943 mL | |
| 80 mM | 0.0478 mL | 0.2392 mL | 0.4783 mL | 1.1958 mL | |
| 100 mM | 0.0383 mL | 0.1913 mL | 0.3826 mL | 0.9566 mL |
aPKC-IN-2 Related Classifications
HY-W030338 Related Classifications
Powered by Bioz