p38α inhibitor 6
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC50 of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7.
For research use only. We do not sell to patients.
- Formula: C25H19BrN6O
- Molecular Weight:499.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
p38α inhibitor 6 (compound 19) inhibits UO-31 cells growth with the IC50 of 1.14 μM[1].
p38α inhibitor 6 (1.14μM, 24 h) increases accumulations of the cells at G0 and G2/M phase in UO-31 cells[1].
p38α inhibitor 6 (1.14μM, 24 h) induces cell apoptosis in UO-31 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 499.36
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Formula C25H19BrN6O
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SMILES
BrC1=CC=CC(N2C(N=CN=C3NC4=CC=C(C(NC5=CC=C(C)C=C5)=O)C=C4)=C3C=N2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p38α inhibitor 6 Related Classifications
HY-159938 Related Classifications
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