RIPK2-IN-7
RIPK2-IN-7 (Compound 10w) is an orally active, selective RIPK2 inhibitor (IC50: 0.6 nM). RIPK2-IN-7 inhibits RIPK2 kinase activity, blocks the nucleotide-binding oligomerization domain (NOD) signaling pathway, and reduces the production of inflammatory factors (such as TNFα). RIPK2-IN-7 can be used in the study of inflammatory bowel disease (IBD).
For research use only. We do not sell to patients.
- CAS No.: 2789711-40-4
- Formula: C19H22FN5
- Molecular Weight:339.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RIPK2 0.6 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
0.3 nM
Compound: 10w
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Inhibition of LPS/MDP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells by ELISA relative to control
Inhibition of LPS/MDP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells by ELISA relative to control
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[PMID: 35709396] |
| H9c2 | IC50 |
12.33 μM
Compound: 10w
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Toxicity in rat H9c2 cells assessed as inhibitory rate
Toxicity in rat H9c2 cells assessed as inhibitory rate
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[PMID: 35709396] |
Chemical Information
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CAS No. 2789711-40-4
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Molecular Weight 339.41
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Formula C19H22FN5
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SMILES
NC1=C2C(C3=C(C=C(C=C3)C)F)=CN([C@H]4CC[C@H](CC4)N)C2=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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