Butrin 

Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis^[1][2][3].

Butrin (10-120 μM; 24-48 h) inhibits SW480 human colorectal cancer cell proliferation with an IC₅₀ of 40 μM, while sparing IHH human hepatocyte cells^[1].
Butrin (40 μM; 48 h) induces both early and late apoptosis in SW480 human colorectal cancer cells with nuclear condensation and fragmentation^[1].
Butrin (40 μM; 48 h) disrupts mitochondrial membrane potential and increases intracellular ROS production in SW480 human colorectal cancer cells^[1].
Butrin (40 μM; 48 h) upregulates pro-apoptotic gene expression and downregulates cell cycle and Wnt pathway gene expression in SW480 human colorectal cancer cells^[1].
Butrin (40 μM; 48 h) upregulates pro-apoptotic and tumor suppressor protein expression and downregulates anti-apoptotic, cell cycle, and Wnt pathway protein expression in SW480 human colorectal cancer cells^[1].
Butrin (1-10 µg/mL; 2-hour pretreatment) inhibits PMACI-induced TNF-α, IL-6 and IL-8 levels and inhibits NF-κB p65 activation in HMC-1 human mast cells^[3].
Butrin (5-1000 ng/mL) inhibits recombinant human IKK kinase activity in a concentration-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

596.53

C₂₇H₃₂O₁₅

492-13-7

O[C@H]1[C@H](OC2=CC3=C(C=C2)C(C[C@@H](C4=CC(O[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)=C(O)C=C4)O3)=O)O[C@H](CO)[C@@H](O)[C@@H]1O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Subramaniyan B, et al. Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. Biomed Pharmacother. 2017;90:402-413.

  [2]. Prabhu A D, et al. Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights[J]. Current Drug Research Reviews, 2025.

  [3]. Rasheed Z, et al. Butrin, isobutrin and butein from medicinal plant Butea monosperma selectively inhibit NF-κB in activated human mast cells: suppression of TNF-α, IL-6 and IL-8[J]. J Pharmacol Exp Ther, 2010, 1: 1-34.  [Content Brief]