492-13-7
Chemical Structure
Butrin
- CAS No.: 492-13-7
- Formula:C27H32O15
- Molecular Weight:596.53
IUPAC Name: 2-(4-hydroxy-3-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-7-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
InChIKey: QVCQYYYTMIZOGK-VQBAZXIRSA-N
SMILES: O[C@H]1[C@H](OC2=CC3=C(C=C2)C(C[C@@H](C4=CC(O[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)=C(O)C=C4)O3)=O)O[C@H](CO)[C@@H](O)[C@@H]1O
Biological Activity: Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis[1][2][3].
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Butrin | Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Subramaniyan B, et al. Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. Biomed Pharmacother. 2017;90:402-413. [Content Brief]
- [2]. Prabhu A D, et al. Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights[J]. Current Drug Research Reviews, 2025.
- [3]. Rasheed Z, et al. Butrin, isobutrin and butein from medicinal plant Butea monosperma selectively inhibit NF-κB in activated human mast cells: suppression of TNF-α, IL-6 and IL-8[J]. J Pharmacol Exp Ther, 2010, 1: 1-34. [Content Brief]
