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Cat. No.: HY-126031

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(R)-KT109

(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC₅₀ values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation.

For research use only. We do not sell to patients.

CAS No.: 2055172-60-4
Formula: C₂₇H₂₆N₄O
Molecular Weight:422.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(R)-KT109 Chemical Structure

CAS No.: 2055172-60-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

DAGLα

9.1 (pIC₅₀)

DAGLβ

8.2 (pIC₅₀)

All DAGL Isoforms :

In Vitro

(R)-KT109 (0.1-1000 nM) selectively inhibits ABHD6 in mouse brain membrane proteome at concentrations ranging from 0.1 to 1000 nM^[1].
(R)-KT109 (10 μM; 30 min) inhibits 99% of endogenous DAGLα and 95% of endogenous ABHD6 in mouse brain membrane proteome^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2055172-60-4
Molecular Weight 422.52
Formula C₂₇H₂₆N₄O
SMILES

O=C(N1C=C(C2=CC=C(C3=CC=CC=C3)C=C2)N=N1)N4[C@H](CCCC4)CC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng H, Kooijman S, Van Den Nieuwendijk A M C H, et al. Triazole ureas act as diacylglycerol lipase inhibitors and prevent fasting-induced refeeding[J]. Journal of Medicinal Chemistry, 2017, 60(1): 428-440.

[2]. Deng H. Chemical tools to modulate endocannabinoid biosynthesis[J]. Medicinal Chemistry, 2013, 56: 8270-8279.

[3]. Deng H, et al. Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors. Medchemcomm. 2017;8(5):982-988. Published 2017 Mar 10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(R)-KT109

All DAGL Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(R)-KT109 Related Classifications

HY-126031 Related Classifications