Ilekudinol B 

Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC₅₀ of 5.3 μM and a K_i of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC₅₀ of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases^[1][2][3][4].

Ilekudinol B (0.1-10 μg/mL) inhibits TNF-α-induced IL-8 production in HT29 cells^[3].
Ilekudinol B (1-50 μM; 1 h 20 min) enhances glucose uptake in L6 myotubes by 1.6-fold (basal) and 2.9-fold (insulin-stimulated)^[4].
Ilekudinol B (1-50 μM; 24 h, 48 h) does not exhibit cytotoxicity in L6 myoblasts at concentrations up to 50 μM after 24 or 48 h of treatment^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

456.66

C₂₉H₄₄O₄

242794-72-5

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Na M, et al. Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis. Phytother Res. 2010;24(11):1716-1719.  [Content Brief]

  [2]. Thuong PT, et al. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull. 2006;29(4):830-833.  [Content Brief]

  [3]. Thuong PT, et al. Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis. Arch Pharm Res. 2005;28(10):1135-1141.  [Content Brief]

  [4]. Lee MS, et al. Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother Res. 2010;24(1):49-53.  [Content Brief]