Ilekudinol B
Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 242794-72-5
- Formula: C29H44O4
- Molecular Weight:456.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ACAT |
IL-8 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
10 μM
Compound: 26
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Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
|
[PMID: 27797185] |
Ilekudinol B (0.1-10 μg/mL) inhibits TNF-α-induced IL-8 production in HT29 cells[3].
Ilekudinol B (1-50 μM; 1 h 20 min) enhances glucose uptake in L6 myotubes by 1.6-fold (basal) and 2.9-fold (insulin-stimulated)[4].
Ilekudinol B (1-50 μM; 24 h, 48 h) does not exhibit cytotoxicity in L6 myoblasts at concentrations up to 50 μM after 24 or 48 h of treatment[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L6 myoblasts
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Concentration:1-50 μM
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Incubation Time:24 h; 48 h
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Result:Showed no significant reduction in cell viability compared to vehicle control at concentrations up to 50 μM after 24 h or 48 h of treatment.
Chemical Information
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CAS No. 242794-72-5
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Molecular Weight 456.66
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Formula C29H44O4
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SMILES
C[C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C[C@H]([C@@H](C5=C)O)O)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Na M, et al. Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis. Phytother Res. 2010;24(11):1716-1719. [Content Brief]
[2]. Thuong PT, et al. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull. 2006;29(4):830-833. [Content Brief]
[3]. Thuong PT, et al. Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis. Arch Pharm Res. 2005;28(10):1135-1141. [Content Brief]
[4]. Lee MS, et al. Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother Res. 2010;24(1):49-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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