242794-72-5
Chemical Structure
Ilekudinol B
- CAS No.: 242794-72-5
- Formula:C29H44O4
- Molecular Weight:456.66
InChIKey: RDOIACMZJPLQIZ-FNVOJQHCSA-N
SMILES: C[C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C[C@H]([C@@H](C5=C)O)O)C)C
Biological Activity: Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases[1][2][3][4].
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Ilekudinol B | Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases. | |||||||||||||||||||||
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- [1]. Na M, et al. Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis. Phytother Res. 2010;24(11):1716-1719. [Content Brief]
- [2]. Thuong PT, et al. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull. 2006;29(4):830-833. [Content Brief]
- [3]. Thuong PT, et al. Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis. Arch Pharm Res. 2005;28(10):1135-1141. [Content Brief]
- [4]. Lee MS, et al. Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother Res. 2010;24(1):49-53. [Content Brief]
Keywords