KOR agonist 7
KOR agonist 7 (Compound 29) is a highly selective κ-opioid receptor (KOR) agonist with a Ki of 138 nM. KOR agonist 7 shows no activity at μ- and δ-opioid receptors or σ1 receptor, and exhibits extremely low affinity for σ2 receptor (Ki = 2.8 μM). KOR agonist 7 significantly reduces the secretion of pro-inflammatory cytokines such as IL-6, TNF-α, and IFN-γ, while increasing the production of the anti-inflammatory cytokine IL-10. KOR agonist 7 downregulates the expression of the pro-inflammatory M1 macrophage marker CD80 and upregulates the anti-inflammatory M2 macrophage marker CD163. KOR agonist 7 holds potential for applications in analgesia and immune modulation.
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- Fòrmula: C21H28Cl2N2O2
- Peso molecular:411.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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κ Opioid Receptor/KOR 138 nM (Ki) |
σ2 2.8 μM (Ki) |
IL-6 |
IL-10 |
Chemical Information
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Peso molecular 411.37
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Fòrmula C21H28Cl2N2O2
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SMILES
O[C@](CN1C(CC2=CC=C(Cl)C(Cl)=C2)=O)(C)[C@H]3CC[C@@H](N4CCCC4)[C@@H]1C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KOR agonist 7 Related Classifications
HY-178945 Related Classifications
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