7-O-Methyl glabranin
7-O-Methyl glabranin is a flavonoid compound and also an inhibitor of LPS-induced TNF-α and IL-1β production. 7-O-Methyl glabranin can be used in the research of diseases such as inflammation.
For research use only. We do not sell to patients.
- CAS No.: 75291-75-7
- Formula: C21H22O4
- Molecular Weight:338.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
TNF-α |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 320DM | IC50 |
24.2 μM
Compound: 3
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Cytotoxicity against human COLO320DM cells after 72 hrs by WST-8 assay
Cytotoxicity against human COLO320DM cells after 72 hrs by WST-8 assay
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[PMID: 20219370] |
7-O-Methyl glabranin (Compound 6) (6 h-12 h) moderately inhibits LPS (HY-D1056)-induced production of TNF-α and IL-1β in RAW 264.7 and J774A.1 cells. Its IC50 values against TNF-α are 41.20 μM in RAW 264.7 cells and 35.50 μM in J774A.1 cells, while the IC50 values against IL-1β are 59.23 μM in RAW 264.7 cells and 62.32 μM in J774A.1 cells. Meanwhile, it maintains high cell viability at a concentration of 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 and J774A.1 cells
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Concentration:100 μM
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Incubation Time:6 h (TNF-α measurement); 12 h (IL-1β measurement)
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Result:Maintained high cell viability of 92.11% in J774A.1 cells at 100 μM.
Chemical Information
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CAS No. 75291-75-7
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Molecular Weight 338.40
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Formula C21H22O4
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SMILES
C/C(C)=C/CC(C(OC)=CC(O)=C12)=C1OC(C3=CC=CC=C3)CC2=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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