7-O-Methyl glabranin 

7-O-Methyl glabranin is a flavonoid compound and also an inhibitor of LPS-induced TNF-α and IL-1β production. 7-O-Methyl glabranin can be used in the research of diseases such as inflammation^[1].

7-O-Methyl glabranin (Compound 6) (6 h-12 h) moderately inhibits LPS (HY-D1056)-induced production of TNF-α and IL-1β in RAW 264.7 and J774A.1 cells. Its IC₅₀ values against TNF-α are 41.20 μM in RAW 264.7 cells and 35.50 μM in J774A.1 cells, while the IC₅₀ values against IL-1β are 59.23 μM in RAW 264.7 cells and 62.32 μM in J774A.1 cells. Meanwhile, it maintains high cell viability at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

338.40

C₂₁H₂₂O₄

75291-75-7

C/C(C)=C/CC(C(OC)=CC(O)=C12)=C1OC(C3=CC=CC=C3)CC2=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Patel NK, et al. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: in vitro and in vivo experimentation. Phytomedicine. 2014;21(7):946-953.  [Content Brief]