TLR8 agonist 8
TLR8 agonist 8 (Compound II-72) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 8 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 8 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 89%.
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- CAS No.: 3034750-58-5
- Formula: C53H63N11O10
- Molecular Weight:1014.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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TLR8 |
Chemical Information
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CAS No. 3034750-58-5
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Molecular Weight 1014.14
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Formula C53H63N11O10
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SMILES
O=C(CNC(CCCCCN1C(C=CC1=O)=O)=O)NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(N3CC4=CC(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)=CN=C4CC3)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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