1. MAPK/ERK Pathway
  2. p38 MAPK

SCIO-469 (Synonyms: Talmapimod)

Cat. No.: HY-10406 Purity: 98.07%
Handling Instructions

SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.

For research use only. We do not sell to patients.
SCIO-469 Chemical Structure

SCIO-469 Chemical Structure

CAS No. : 309913-83-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 163 In-stock
5 mg USD 144 In-stock
10 mg USD 228 In-stock
25 mg USD 480 In-stock
50 mg USD 804 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

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Description

SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases. target: p38 IC50: 9 nM; [1] In vitro: SCIO-469 decreased constitutive p38α MAPK phosphorylation of both 5T2MM and 5T33MM cells. SCIO-469 also inhibits secretion and expression of the osteoclast-activating factors IL-11, receptor activator of NF-κB ligand, and macrophage inflammatory protein 1α, and prevents human osteoclast activationIn. It can also inhibit multiple myeloma growth and prevents bone disease in the 5T2MM and 5T33MM models. In vivo: targeting p38α MAPK with SCIO-469 decreases myeloma burden in addition to preventing the development of myeloma bone disease. [2]

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9493 mL 9.7466 mL 19.4932 mL
5 mM 0.3899 mL 1.9493 mL 3.8986 mL
10 mM 0.1949 mL 0.9747 mL 1.9493 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

513.0

Formula

C₂₇H₃₀ClFN₄O₃

CAS No.

309913-83-5

SMILES

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[[email protected]](C)CN(CC4=CC=C(F)C=C4)[[email protected]@H](C)C3)=O)C(Cl)=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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SCIO-469
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HY-10406
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