2. Others MAPK/ERK Pathway Apoptosis Immunology/Inflammation Protein Tyrosine Kinase/RTK
  3. Reference Standards p38 MAPK TNF Receptor Interleukin Related VEGFR Apoptosis
  4. Talmapimod (Standard)

Talmapimod (Standard)  (Synonyms: SCIO-469 (Standard))

Cat. No.: HY-10406R
Handling Instructions Technical Support

Talmapimod (Standard) is the analytical standard of Talmapimod (HY-10406). This product is intended for research and analytical applications. Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC50 of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome).

For research use only. We do not sell to patients.

Talmapimod (Standard)

Talmapimod (Standard) Chemical Structure

CAS No. : 309913-83-5

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Information

Talmapimod (Standard) is the analytical standard of Talmapimod (HY-10406). This product is intended for research and analytical applications. Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC50 of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

513.00

Formula

C27H30ClFN4O3
CAS No.
SMILES

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Talmapimod (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talmapimod (Standard)309913-83-5SCIO-469 (Standard)Reference Standardsp38 MAPKTNF ReceptorInterleukin RelatedVEGFRApoptosisTumor Necrosis Factor ReceptorTNFRILVascular endothelial growth factor receptormultiplemyelomacellsHsp27tumorcytotoxicityphosphorylationInhibitorinhibitorinhibit

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