Amorfrutin A
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis.
For research use only. We do not sell to patients.
- CAS No.: 80489-90-3
- Formula: C21H24O4
- Molecular Weight:340.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.458 μM
Compound: amorfrutin 1
|
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
|
[PMID: 23286787] |
| HEK293 | EC50 |
0.458 μM
Compound: amorfrutin 1
|
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
|
[PMID: 25734377] |
| HeLa | IC50 |
0.84 μM
Compound: 6
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Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
|
[PMID: 18841906] |
| HT-29 | IC50 |
50.8 μM
Compound: 1
|
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
|
[PMID: 25938459] |
| RAW264.7 | IC50 |
4.17 μM
Compound: 6
|
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
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[PMID: 18841906] |
| THP-1 | IC50 |
50 μM
Compound: 22
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Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
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[PMID: 28075580] |
Chemical Information
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CAS No. 80489-90-3
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Molecular Weight 340.41
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Formula C21H24O4
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SMILES
O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)\C)=C1O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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