Nrf2 activator-27
Nrf2 activator-27 is a Nrf2 activator with anti-inflammatory activity. Nrf2 activator-27 increases the expression level of Nrf2, promotes its nuclear translocation, and upregulates the downstream target proteins HO-1 and NQO1. Nrf2 activator-27 reduces the production of NO, TNF-α, IL-1β and IL-6 in LPS-stimulated macrophages. Nrf2 activator-27 can be used for the research of inflammation-related diseases.
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- Fòrmula: C18H19NO5
- Peso molecular:329.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
IL-6 |
IL-1β |
TNF-α |
NQO1 |
In Vitro
Nrf2 activator-27 (compound 5-S) (1.25-40 μM; 1 h pre-incubation, followed by 24 h LPS stimulation) potently inhibits LPS-induced NO production in RAW264.7 macrophages, with an IC50 value of 5.89 μM[1].
Nrf2 activator-27 (3-12 μM; 1 h pre-incubation) reduces the production of TNF-α, IL-1β and IL-6 in LPS-stimulated RAW264.7 macrophages in a dose-dependent manner[1].
Nrf2 activator-27 (3-12 μM; 1 h pre-incubation) activates the Nrf2 pathway in a dose-dependent manner in RAW264.7 macrophages by upregulating Nrf2 expression, promoting its nuclear translocation, and upregulating the downstream target proteins HO-1 and NQO1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:3, 6, 12 μM (Nrf2 pathway activation analysis)
6 μM (nuclear translocation analysis) -
Incubation Time:1 h pre-incubation, followed by LPS stimulation
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Result:Increased Nrf2 protein expression in a concentration-dependent manner, accompanied by upregulation of the downstream target proteins HO-1 and NQO1.
Increased the amount of Nrf2 in the nuclear fraction of RAW264.7 macrophages.
Chemical Information
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Peso molecular 329.35
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Fòrmula C18H19NO5
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SMILES
[H][C@]1(CC2)C3=CC=C(OC(C(CC(OC)=O)=C)=O)C=C3CCN1C2=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nrf2 activator-27 Related Classifications
HY-184690 Related Classifications
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