CJ-14897
CJ-14897 is a cytokine production inhibitor, with IC50 values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC50 of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624.
For research use only. We do not sell to patients.
- CAS No.: 377755-95-8
- Formula: C12H15NO5
- Molecular Weight:253.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β 59 nM (IC50) |
CJ-14,897 potently inhibits LPS (HY-D1056)-induced production of IL-1β and TNF-α in human whole blood, with IC50 values of 0.059 μM and 0.59 μM, respectively; meanwhile, this compound shows weak inhibitory activity against total protein synthesis, with an IC50 of 180 μM[1].
CJ-14897 inhibits LPS-induced production of IL-1β and TNF-α in human whole blood, with IC50 values ranging from 0.059 to 2.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 377755-95-8
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Molecular Weight 253.25
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Formula C12H15NO5
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SMILES
CC(O[C@@H](C)[C@H](C1=CN=C(C(OC)=O)C=C1)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CJ-14897 Related Classifications
HY-182630 Related Classifications
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