Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp

  • J Antibiot (Tokyo). 2001 Sep;54(9):703-9. doi: 10.7164/antibiotics.54.703.
K Ichikawa  1 ,  H Hirai ,  M Ishiguro ,  T Kambara ,  Y Kato ,  Y J Kim ,  Y Kojima ,  Y Matsunaga ,  H Nishida ,  Y Shiomi ,  N Yoshikawa ,  N Kojima
Affiliations
  • 1. Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., Chita-gun, Aichi, Japan. [email protected]
PMID: 11714225 DOI: 10.7164/antibiotics.54.703
Abstract

New cytokine production inhibitors, CJ-14,877 (I) and CJ-14,897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7S,8S)-5-(7,8-dihydroxypropyl)pyridine-2-carboxylate and methyl-(7S,8S)-5-(8-acetoxy-7-hydroxypropyl)pyridine-2-carboxylate [corrected], respectively, by spectroscopic analyses. These compounds showed inhibitory activities for lipopolysaccharide-induced production of interleukin-1beta and tumor necrosis factor-alpha in human whole blood with IC50 values of the range from 0.059 to 2.6 microM.

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