2. NF-κB Stem Cell/Wnt PI3K/Akt/mTOR Apoptosis Immunology/Inflammation
  3. Keap1-Nrf2 GSK-3 TNF Receptor Interleukin Related SOD
  4. Isoeucommin A

Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy.

For research use only. We do not sell to patients.

Isoeucommin A

Isoeucommin A Chemical Structure

CAS No. : 134859-90-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Isoeucommin A Related Antibodies

Top Publications Citing Use of Products

View All GSK-3 Isoform Specific Products:

View All Isoforms
GSK-3 GSK-3α GSK-3β

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy[1].

In Vitro

Isoeucommin A (31.25-125 μM; 24 h) activates the Nrf2/HO-1 pathway in normal human renal mesangial cells (HRMCs)[1].
Isoeucommin A (61.3-125 μM; 24 h) activates the Nrf2/HO-1 pathway in high glucose (HG)-stimulated HRMCs by increasing p-GSK-3β levels[1].
Isoeucommin A (31.25-125 μM; 24 h) enhances the antioxidant capacity of HRMCs stimulated by high glucose (HG)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isoeucommin A Related Antibodies

Western Blot Analysis[1]

Cell Line: normal human renal mesangial cells (HRMCs)
Concentration: 31.25 μM, 61.3 μM, 125 μM
Incubation Time: 24 h
Result: Significantly increased Nrf2 protein expression at 31.25 μM.
Significantly increased both Nrf2 and HO-1 protein expression at 61.3 μM and 125 μM, with the highest concentration (125 μM) producing the greatest increase in protein levels.

Western Blot Analysis[1]

Cell Line: high-glucose (HG)-stimulated human renal mesangial cells (HRMCs)
Concentration: 61.3 μM, 125 μM
Incubation Time: 24 h
Result: Significantly increased p-GSK-3β protein expression, the p-GSK-3β/GSK-3β ratio, Nrf2 protein expression, and HO-1 protein expression compared to the HG-only group, with 125 μM producing the most robust increases.
In Vivo

Isoeucommin A (2.5-10 mg/kg; intravenous injection; once daily; for 28 consecutive days) dose-dependently activates the Nrf2/HO-1 pathway, thereby improving renal dysfunction, tissue damage, inflammation and oxidative stress in rats with streptozotocin (HY-13753)-induced diabetic nephropathy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 8 weeks old, STZ-induced diabetic nephropathy)[1]
Dosage: 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: i.v.; daily; 28 days
Result: Reduced blood glucose and increased body weight gain significantly in the high-dose group compared to the DN model group.
Reduced kidney index, serum blood urea nitrogen, serum and urine creatinine, and urinary albumin-to-creatinine ratio significantly in medium- and high-dose groups compared to the DN model group.
Reduced serum TNF-α, IL-1β, IL-6, and kidney tissue MDA levels significantly, and increased kidney tissue SOD and GSH levels significantly in all dose groups compared to the DN model group, with effects increasing in a dose-dependent manner.
Reduced inflammatory cell infiltration, glomerular enlargement, renal tubular dilation, and renal tubular epithelial cell vacuolation in a dose-dependent manner, with the high-dose group nearing normal tissue morphology.
Increased renal Nrf2 and HO-1 mRNA and protein expression in a dose-dependent manner, with statistically significant elevations compared to the DN model group.
Molecular Weight

550.55

Formula

C27H34O12
CAS No.
SMILES

COC1=C(O)C(OC)=CC([C@@H]2[C@]3([H])[C@@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)OC3)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Isoeucommin A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoeucommin A134859-90-8Keap1-Nrf2GSK-3TNF ReceptorInterleukin RelatedSODGlycogen synthase kinase-3Glycogen synthase kinase 3Tumor Necrosis Factor ReceptorTNFRILSuperoxide DismutaseHO-1IL-1βIL-6TNF-αGSHrenal mesangial cellsMDAGSK-3βNrf2lignan compoundSprague Dawley ratdiabetic nephropathyInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Isoeucommin A
Cat. No.:
HY-N19615
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.