Pandanus tonkinensis Martelli ex B. C. Stone
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Pandanus tonkinensis Martelli ex B. C. Stone (1)
Isoeucommin A
Cat. No.: HY-N19615
CAS No.: 134859-90-8
- Formula: C27H34O12
- Molecular Weight: 550.55
Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy.
