1. Immunology/Inflammation
    Apoptosis
  2. Toll-like Receptor (TLR)
    TNF Receptor
  3. Kdo2-Lipid A ammonium

Kdo2-Lipid A ammonium 

Cat. No.: HY-N8277
Handling Instructions

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.

For research use only. We do not sell to patients.

Kdo2-Lipid A ammonium Chemical Structure

Kdo2-Lipid A ammonium Chemical Structure

CAS No. : 1246298-62-3

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Description

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2[1].

IC50 & Target

TLR4

 

In Vitro

Kdo2-Lipid A (1 µM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: TNF and PGE2
Concentration: 1 µM
Incubation Time:
Result: Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.
In Vivo

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (Male Holzman Sprague-Dawley, 300–400 g) [1]
Dosage: 0.1 to 10 µg
Administration: I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result: Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.
Molecular Weight

2306.84

Formula

C₁₁₀H₂₁₄N₆O₃₉P₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Kdo2-Lipid A ammonium
Cat. No.:
HY-N8277
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