Kdo2-Lipid A ammonium
Based on 3 publication(s) in Google Scholar
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.
For research use only. We do not sell to patients.
- Purity: 95.2%
- CAS No.: 1246298-62-3
- Formula: C110H214N6O39P2
- Molecular Weight:2306.84
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Kdo2-Lipid A ammonium
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Biological Activity
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TLR4 |
Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TNF and PGE2
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Concentration:1 µM
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Incubation Time:
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Result:Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats (Male Holzman Sprague-Dawley, 300–400 g) [1]
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Dosage:0.1 to 10 µg
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Administration:I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
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Result:Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1246298-62-3
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Appearance Solid
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Molecular Weight 2306.84
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Formula C110H214N6O39P2
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Color White to off-white
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SMILES
O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N
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Structure Classification
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Initial Source
E. coli
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Inflammation
PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF-κB and NLRP3 Pathways. [Abstract]2023 Feb;46(1):115-128. PMID: 35930089 -
Mol Immunol
CXCL2-TLR4 axis activates NETs by accelerating autophagy through ATG7 to promote the progression of idiopathic interstitial pneumonia. [Abstract]2025 Dec 23:189:226-234. PMID: 41443150 -
Purity & Documentation
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kdo2-Lipid A ammonium Related Classifications
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