β-Bisabolol 

β-Bisabolol is a potent anti-inflammatory agent that can be found in cotton gin trash. β-Bisabolol inhibits the production of nitric oxide (NO), pGE₂, TNF-α, IL-6, and IL-8 in LPS (HY-D1056)-stimulated macrophages and fibroblast cells. β-Bisabolol can be used for the research on inflammatory conditions^[1].

β-Bisabolol (1.6-100.0 μg/mL; 24 h) is non-toxic to RAW 264.7 macrophages, 3t3 fibroblasts, and HS27 fibroblasts up to 50 μg/mL, with slight toxicity observed at 100.0 μg/mL^[1].
β-Bisabolol (1.6-50.0 μg/mL; 1 h pretreat) dose-dependently inhibits the production of NO, PGE2, and TNF-α in LPS-stimulated RAW 264.7 macrophages, as well as IL-6 (with EC₅₀ values of 4.3 μg/mL in 3T3, 8.8 μg/mL in HS27, respectively) and IL-8 in LPS-stimulated fibroblast cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

222.37

C₁₅H₂₆O

15352-77-9

[C@@H](CCC=C(C)C)(C)[C@]1(O)CCC(C)=CC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Egbuta MA, et al. In Vitro Anti-Inflammatory Activity of Essential Oil and β-Bisabolol Derived from Cotton Gin Trash. Molecules. 2022;27(2):526. Published 2022 Jan 14.  [Content Brief]