β-Bisabolol
β-Bisabolol is a potent anti-inflammatory agent that can be found in cotton gin trash. β-Bisabolol inhibits the production of nitric oxide (NO), pGE2, TNF-α, IL-6, and IL-8 in LPS (HY-D1056)-stimulated macrophages and fibroblast cells. β-Bisabolol can be used for the research on inflammatory conditions.
For research use only. We do not sell to patients.
- CAS No.: 15352-77-9
- Formula: C15H26O
- Molecular Weight:222.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-8 |
β-Bisabolol (1.6-100.0 μg/mL; 24 h) is non-toxic to RAW 264.7 macrophages, 3t3 fibroblasts, and HS27 fibroblasts up to 50 μg/mL, with slight toxicity observed at 100.0 μg/mL[1].
β-Bisabolol (1.6-50.0 μg/mL; 1 h pretreat) dose-dependently inhibits the production of NO, PGE2, and TNF-α in LPS-stimulated RAW 264.7 macrophages, as well as IL-6 (with EC50 values of 4.3 μg/mL in 3T3, 8.8 μg/mL in HS27, respectively) and IL-8 in LPS-stimulated fibroblast cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7, 3t3, HS27 cells
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Concentration:1.6, 3.1, 6.3, 12.5, 25.0, 50.0, 100.0 μg/mL
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Incubation Time:24 h
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Result:Found no effect on cell viability at concentrations up to 50.0 μg/mL in RAW 264.7, 3t3 and HS27 cells.
Showed slight toxicity at 100.0 μg/mL in RAW 264.7, 3t3 and HS27 cells.
Chemical Information
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CAS No. 15352-77-9
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Molecular Weight 222.37
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Formula C15H26O
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SMILES
[C@@H](CCC=C(C)C)(C)[C@]1(O)CCC(C)=CC1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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