TNF/IFN-γ-IN-1
Based on 1 Customer Validation
TNF/IFN-γ-IN-1 (compound TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFN-γ-IN-1 can used in study Alzheimer’s disease.
For research use only. We do not sell to patients.
- Purity: 99.39%
- CAS No.: 876013-29-5
- Formula: C20H23N3O6
- Molecular Weight:401.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
>10000 nM
Compound: Hb
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Cytotoxicity against breast cancer MDA-MB-231 cell line by MTT assay
Cytotoxicity against breast cancer MDA-MB-231 cell line by MTT assay
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[PMID: 16420033] |
Chemical Information
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CAS No. 876013-29-5
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Appearance Solid
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Molecular Weight 401.41
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Formula C20H23N3O6
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Color Off-white to light brown
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SMILES
COC1=C(OC)C(OC)=CC(C2=CN(C3=CC(OC)=C(OC)C(OC)=C3)N=N2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (249.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4912 mL | 12.4561 mL | 24.9122 mL | 62.2805 mL |
| 5 mM | 0.4982 mL | 2.4912 mL | 4.9824 mL | 12.4561 mL | |
| 10 mM | 0.2491 mL | 1.2456 mL | 2.4912 mL | 6.2280 mL | |
| 15 mM | 0.1661 mL | 0.8304 mL | 1.6608 mL | 4.1520 mL | |
| 20 mM | 0.1246 mL | 0.6228 mL | 1.2456 mL | 3.1140 mL | |
| 25 mM | 0.0996 mL | 0.4982 mL | 0.9965 mL | 2.4912 mL | |
| 30 mM | 0.0830 mL | 0.4152 mL | 0.8304 mL | 2.0760 mL | |
| 40 mM | 0.0623 mL | 0.3114 mL | 0.6228 mL | 1.5570 mL | |
| 50 mM | 0.0498 mL | 0.2491 mL | 0.4982 mL | 1.2456 mL | |
| 60 mM | 0.0415 mL | 0.2076 mL | 0.4152 mL | 1.0380 mL | |
| 80 mM | 0.0311 mL | 0.1557 mL | 0.3114 mL | 0.7785 mL | |
| 100 mM | 0.0249 mL | 0.1246 mL | 0.2491 mL | 0.6228 mL |
TNF/IFN-γ-IN-1 Related Classifications
HY-161016 Related Classifications
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