LEESGGGLVQPGGSMK acetate

Name: LEESGGGLVQPGGSMK acetate
Brand: MedChemExpress
SKU: HY-P3149B
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3149B Purity: 99.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LEESGGGLVQPGGSMK acetate, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK acetate can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LEESGGGLVQPGGSMK acetate Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of LEESGGGLVQPGGSMK acetate:

LEESGGGLVQPGGSMK Get quote
LEESGGGLVQPGGSMK TFA Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

The anti-TNF antibodies blocking the action of TNF alpha revolutionized therapy of TNF-related diseases such as Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. By neutralizing TNF activity, anti-TNF antibodies promote mucosal healing and induce long-term remissions in vivo. The main anti-TNF antibodies that are currently authorized encompass Infliximab, Etanercept, Adalimumab, Certolizumab and Golimumab^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1605.76

Formula

C₆₆H₁₁₂N₁₈O₂₆S

Appearance

Solid

Color

White to off-white

Sequence Shortening

LEESGGGLVQPGGSMK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (62.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6228 mL	3.1138 mL	6.2276 mL
5 mM	0.1246 mL	0.6228 mL	1.2455 mL
10 mM	0.0623 mL	0.3114 mL	0.6228 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (62.28 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (243 KB) RP-HPLC (112 KB) MS (246 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Dorothée LEBERT, et al. A method for quantifying therapeutic antibodies. EP3371592A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6228 mL	3.1138 mL	6.2276 mL	15.5690 mL
	5 mM	0.1246 mL	0.6228 mL	1.2455 mL	3.1138 mL
	10 mM	0.0623 mL	0.3114 mL	0.6228 mL	1.5569 mL
	15 mM	0.0415 mL	0.2076 mL	0.4152 mL	1.0379 mL
	20 mM	0.0311 mL	0.1557 mL	0.3114 mL	0.7784 mL
	25 mM	0.0249 mL	0.1246 mL	0.2491 mL	0.6228 mL
	30 mM	0.0208 mL	0.1038 mL	0.2076 mL	0.5190 mL
	40 mM	0.0156 mL	0.0778 mL	0.1557 mL	0.3892 mL
	50 mM	0.0125 mL	0.0623 mL	0.1246 mL	0.3114 mL
	60 mM	0.0104 mL	0.0519 mL	0.1038 mL	0.2595 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.