MAO-B-IN-21
MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model.
For research use only. We do not sell to patients.
- CAS No.: 2956426-18-7
- Formula: C24H25ClN2O4
- Molecular Weight:440.92
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
MAO-B |
MAO-B-IN-21 (37.5 μM in methanol) blocks Cu2+-induced ROS production, due to metal-chelating property and/or its antioxidant capacity to capture the free radicals from Cu2+-Ascorbate redox system[1].
MAO-B-IN-21 (25 μM; 24 h; 37 °C) inhibits self-induced Aβ1-42 aggregation and disaggregate self-induced Aβ1-42 fibrils[1].
MAO-B-IN-21 (2.5-25 μM; 24 h) inhibits ROS production in LPS-stimulated BV-2 microglia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MAO-B-IN-21 (8 mg/kg and 32 mg/kg; ig; single dose) shortenes the escape latency time (ELT), reduced Aβ1-42 level, indicating the improvement in learning and memory ability in Aβ-induced AD mice model[1].
Pharmacokinetic Analysis in Balb/C mice[1]
| Tissue | T1/2 | Tmax | Cmax | AUC0-t | AUCbrain/plasma |
| Plasma | 1.15 h | 0.5 h | 1539 ng/mL | 2941 ng·h/mL | 0.69 |
| Brain | 2.07 h | 1.0 h | 922.7 ng/g | 2032.5 ng·h/g |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2956426-18-7
-
Molecular Weight 440.92
-
Formula C24H25ClN2O4
-
SMILES
CCCCCCCC1OC(C2=CC(N3N=C(CC3=O)C4=CC(Cl)=CC=C4O)=CC=C21)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz